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Trying to Conceive: Endometrial Biopsy

Are you trying to conceive? Are you having troubles getting pregnant? An endometrial biopsy can determine if you're ovulating and indicate whether your endometrial tissue can allow a fertilized egg to implant so you can get pregnant.

Your doctor will likely recommend an endometrial biopsy when you're trying to conceive, but:
  • You have irregular periods.
  • You haven't been able to conceive after a year of trying.
  • There is no evidence of male infertility.

The endometrial biopsy is generally taken within a few days prior to expected menstruation when your uterine lining is thickest and most likely to support a pregnancy. Here is how an endometrial biopsy is generally performed:
  • First, your doctor will insert a speculum in your vagina and cleanse your cervix.
  • She'll remove a tissue sample from the uterine lining with a combination of suction and gentle scraping.
  • She can use a pipette, which looks like a thin straw, and/or a curette, which is used to scrape your endometrial lining.

Side effects can include mild cramping, light-headedness, and spotting or bleeding. If you have heavy bleeding, a foul odor from your vagina or a fever after the procedure, contact your doctor immediately.

If you're worried that the procedure may cause a miscarriage in the event that you have conceived, you may find it reassuring that the odds of an endometrial biopsy causing a miscarriage are very small. As with any procedure, check with your doctor about the risks.

If here are any irregularities, your doctor will treat you based upon the findings. If there are signs of infertility, she may prescribe hormones while you try to conceive.
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